-
In this study, we discovered the shared lipid signature associated with long sporadic Parkinson’s disease (PD) (sPD), GBA risk and mild mutations, that is distinct from that of GBA severe mutation in PD amygdala. Moreover, we found that the levels of pathological alpha-synuclein, glucocerebrosidase activity and specific lipids, inc. cholesterol, sphingolipids, cardiolipin and diacylglycerides, correlate in sPD samples. These results provide the first evidence that GBA risk/mild mutations, on one hand, and GBA severe mutation, on the other hand, lead to opposite changes in the lipidome of PD amygdala. Finally, we provide the lipid composition of Lewy Bodies (LBs) and small aggregates (SAs) enriched fractions from PD and…
-
Jesper, Krista, Celine, and Kathi proudly represented both the Galvagnion Group and the University of Copenhagen in this year’s DHL Team Run.
-
Congratulations to Kristina Mojtic who successfully defended her Masters thesis this week and thereby became a Master of Science at the University of Copenhagen. In her project she investigated the effect of small molecule drugs on the activity of GCase enzyme in differentiated SH-SY5Y cells. Cheers!
-
Tuesday evening, Celine Galvagnion gave the Medicinens Verden talk, “What can our skin and brain cells tell us about Parkinson’s?” in front of an engaged and very participating audience at Panum. Thank you all!👌 👏 Céline Galvagnion took us on an instructive journey on how our brain and skin cells can be used to understand the progression of Parkinson’s Disease. This knowledge can be used to design efficient biomarkers and medical treatments against this currently incurable disease that 12.000 people are suffering from, only in Denmark, and so many more worldwide. This was the last talk in the Spring season…
-
11.10.2023 Céline received a 131.300 DKK grant from Parkinsonforeningen for the project “Brain glucosylceramide changes associated with disease duration and familial Parkinson Disease.” This project aims to quantify changes in glucosylceramide levels associated with Parkinson’s Disease in post-mortem brain samples.
-
We would like to welcome Erasmus students Aiofe Davis & Navya Lalu, Master student Kristina Mojtic, Research assistant Krista Stenstrøm and visiting researcher Soumik Ray to the group!
-
We are continuing our journey to a more sustainable way to do our exciting research with our recently awarded LEAF Silver certificate. Many thanks to the members of the group for their great help and efforts to reach this goal.
-
Jesper Elmsted Dreier received a 695 € travel grant from the Federation of European Biochemical Societies (FEBS) to attend the FEBS Advanced Lecture Course entitled “Protein folding, aggregation and compartmentalization”.
-
The Friday bar is a social initiative for employees, PhD Students and students writing their master’s thesis at a department. Last Friday, we enjoyed some live music, food, drinks and good company under the summer sun.
-
Céline Galvagnion received a DKK 2,879,534 grant from Danmarks Frie Forskningsfond for the project “Understanding the cytotoxicity of protein-lipid aggregates in Parkinson’s Disease”. This project aims to investigate the toxicity of protein-lipid aggregates and fibrils in different cellular models of Parkinson’s Disease.
Galvagnion Group 