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Jesper Elmsted Dreier received a 695 € travel grant from the Federation of European Biochemical Societies (FEBS) to attend the FEBS Advanced Lecture Course entitled “Protein folding, aggregation and compartmentalization”.
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Céline Galvagnion received a DKK 2,879,534 grant from Danmarks Frie Forskningsfond for the project “Understanding the cytotoxicity of protein-lipid aggregates in Parkinson’s Disease”. This project aims to investigate the toxicity of protein-lipid aggregates and fibrils in different cellular models of Parkinson’s Disease.
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Céline Galvagnion and her partners received a 1.749.377 € collaborative grant from EraPermed for the project “DEEPEN-iRBD Prodromal DEtErminants for PhENoconversion of idiopathic RBD to alpha-synucleinopathies (PD, DLB and MSA)”. The DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB). The DEEPEN-iRBD study is coordinated by Graziella Cappelletti from the University of Milan and involves partners from Milan Maugeri Clinical Science Institute, the Lund University, the French National Centre for Scientific Research, the Danish Parkinson’s Association and the University of Zagreb. (Twitter; LinkedIn)
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We are excited about Céline being part of the Basic Science Subcommittee in the upcoming World Parkinson Congress that will take place in Barcelona from the 4th until the 7th of July 2023. The World Parkinson Congresses, serve as a global platform where basic scientists, clinical researchers, healthcare professionals, individuals with Parkinson’s, and other stakeholders convene to foster discussions, knowledge exchange, and constructive debates on the most recent scientific breakthroughs, medical advancements, and comprehensive care practices concerning Parkinson’s disease. Read more about it →
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We are thrilled to announce that Céline will be joining the FEBS Special Meeting on Sphingolipid Biology as a speaker. The Meeting, scheduled to take place from the 8th until the 13th of October 2023 in Madeira, proposes to summon the sphingolipid community to discuss about the basic principles of sphingolipid biology and about how they can be integrated to explain the role of sphingolipids in human health. Learn more about it here →
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Using a combination of Small Angle X-ray and Neutron Scattering (SAXS/SANS) measurements, we show that the binding of α-synuclein, the protein involved in Parkinson’s Disease, to negatively charged membranes leads to the fast (<ms) and reversible breakage of vesicles into small, cylindrical and disc-like lipid-protein particles that is followed by a slower (days) and irreversible aggregation process consisting of the co-assembly of α-synuclein and lipid molecules into amyloid fibrils. We hope that these results will help providing a better understanding of the molecular mechanisms leading to the formation of complex protein-lipid assemblies such as the Lewy Bodies found in the brains of…




