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We are thrilled to announce that Céline will be joining the FEBS Special Meeting on Sphingolipid Biology as a speaker. The Meeting, scheduled to take place from the 8th until the 13th of October 2023 in Madeira, proposes to summon the sphingolipid community to discuss about the basic principles of sphingolipid biology and about how they can be integrated to explain the role of sphingolipids in human health. Learn more about it here →
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Only happy faces after a 100km bike ride in one of the most scenic routes close to Copenhagen! Spend the day enjoying the sun, rejuvenating with a dip in the cold Baltic Sea, eating ice-cream and exploring the sights of Helsingør.
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Using a combination of Small Angle X-ray and Neutron Scattering (SAXS/SANS) measurements, we show that the binding of α-synuclein, the protein involved in Parkinson’s Disease, to negatively charged membranes leads to the fast (<ms) and reversible breakage of vesicles into small, cylindrical and disc-like lipid-protein particles that is followed by a slower (days) and irreversible aggregation process consisting of the co-assembly of α-synuclein and lipid molecules into amyloid fibrils. We hope that these results will help providing a better understanding of the molecular mechanisms leading to the formation of complex protein-lipid assemblies such as the Lewy Bodies found in the brains of…
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The DEEPEN-iRBD project, funded by @ERANET_PerMed, aims at defining a model for early risk stratification, diagnosis, treatment, and prognosis of patients with iRBD. We are a multidisciplinary consortium of researchers from Luxembourg, Italy, France, Denmark, Sweden and Croatia. The project kick-off meeting took place in Milan on the 27th of February, 2023, where we had the chance to discuss and envision the progress of the project. Don’t forget to follow us on Twitter to be the first to receive our latest news and updates.
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We want to congratulate Frederik Ravnkilde Marlet for successfully attaining his PhD title on February 2023! After 3 years of dedication, perseverance, and tireless pursuit of knowledge, Frederik has emerged triumphant. He has now started his new journey as a Postdoctoral Researcher in the group and is involved in our Lewy body characterisation project.
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Céline Galvagnion received a DKK 113,000 grant from the Danish Parkinson’s disease foundation (Parkinsonforeningen) to continue our work on investigating the interplay between lipid changes and protein aggregation associated with decreases in glucocerebrosidase protein and activity levels in differentiated SH-SY5Y cells.
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We are thrilled to announce that our publication on “Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation” was selected for an article feature at the KU website. We are happy to see our work receiving recognition and being shared with a wider audience. Read the article here →
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Céline Galvagnion and her collaborators received a DKK 1,072,000 Industrial PhD grant from Innovation Fund Denmark for the project “LRRK2 modulation of lysosomal function and α-synuclein homeostasis – investigation of how LRRK2 mutations lead to Parkinson’s disease”. The project is coordinated by Tau Benned-Jensen at Lundbeck. We are pleased to welcome Josephine Fussing Tengberg in the group.
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Celine’s talk on the influence of lipid composition on the kinetics of α-synuclein aggregation from the 2020-2022 ZOOMinar series on “Molecular Basis of Proteinopathies”
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Céline Galvagnion received a DKK 145,000 grant from the Danish Parkinson’s disease foundation (Parkinsonforeningen) to continue our work on investigating the interplay between lipid changes and protein aggregation associated with decreases in glucocerebrosidase protein and activity levels in differentiated SH-SY5Y cells
Galvagnion Group 