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Congratulations to the new doctor Jesper Elmsted Dreier for successfully defending his PhD thesis! Our group wishes you the best!
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Congratulations to Ana Glavic on her incredible Master’s defense!
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Congratulations to Tristan Kvistgaard Bienkowski and Caroline Vadsholt on successfully defending their Bachelor’s theses!
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Our manuscript “Shared and distinct lipid profiles in amygdala from sporadic and GBA-associated Parkinson’s Disease” is accepted for publication at npj Parkinson’s Disease (IF: 8.2). In this work, we found extensive metabolic remodelling of lipids in amygdala from people with sporadic PD and disease duration above 30 years and from people with PD carriers of a GBA risk mutation. Besides increases in the levels of the substrate of Glucocerebrosidase (GCase), the protein encoded by the gene GBA, i.e. glucosylceramide, and sphingolipids, we observed increased free cholesterol, diacylglyceride and most glycerophospholipids in these samples relative to healthy controls. Moreover, we found a…
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We had a nice time after work at the KU festival. It occurs every year at the University of Copenhagen during spring time, gathering activities and live shows with incredible danish artists.
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In January 15th, Céline had the pleasure and honour to present our research on lipid disruptions associated with Parkinson’s Disease at the event ”En eftermiddag på Lundbeck” / “An afternoon at Lundbeck” to patients with Parkinson’s Disease and their family. Such an outreach event is crucial for our laboratory as it gives us the opportunity to share our results with our most important stakeholders, i.e. patients and their family, and to thank them for trusting us with the use of their samples for our research to advance our understanding of Parkinson’s disease, a first requirement for the design of new…
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Céline, Jesper and Patricia presented our latest results at the Alzheimer’s and Parkinson’s Disease conference in Copenhagen. Céline shared our latest results on lipid changes associated with sporadic and GBA-related Parkinson’s Disease across brain areas. https://lnkd.in/ehSy2mER Jesper presented his work on the mechanism of inhibition of α-synuclein-lipid co-assembly into amyloid fibrils by the small molecule chaperone Ambroxol. https://lnkd.in/eCPs6nb8 Patricia (guest student from Prof. Alessandra Mussi Ribeiro) shared her last results on the effect of the plant extract Eugenia uniflora L. (Pitangueira) on α-synuclein aggregation in cells. Moreover, Céline had the opportunity to describe in a MEDTalk with BestPractice Nordic the…
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New publications! Our manuscript describing the mechanism by which the small molecule chaperone Ambroxol inhibits the co-assembly of alpha-synuclein with lipids into amyloid fibrils is now published at Chemical Science Journal. This collaborative work with Jesper Dreier, Elliot Carles, Katharina Schott, Alisdair Stevenson and Thomas Michaels suggests a novel role of Ambroxol that can act not only by stabilising Glucocerebrosidase but also by preventing alpha-synuclein aggregation, the process associated with Parkinson’s Disease. Thanks to the Novo Nordisk Foundation & Danmarks Frie Forskningsfond for funding.
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On the 10-year anniversary of the National Centre for Excellence in Research on Parkinson’s Disease (NCER-PD) Céline, Krista and Kathi joined the celebratory conference in Luxembourg. Céline gave a talk on our latest findings on lipid changes associated with PD in post-mortem brain samples as well as the newly discovered inhibitory effect of Ambroxol on aS aggregation. Krista gave a flash-talk of her project on lipid changes in iPSC derived neurons and Kathi presented her poster on pre-formed fibrils induced toxicity in cell-based models.
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Congratulations to Helena Thorkildsen (co-supervised with Morten Meyer) and Nefeli Sotiraki on successfully defending their MSc theses.
Galvagnion Group 